The trimeric autotransporter adhesin BadA is required for in vitro biofilm formation by Bartonella henselae
نویسندگان
چکیده
منابع مشابه
Identification of a Predicted Trimeric Autotransporter Adhesin Required for Biofilm Formation of Burkholderia pseudomallei
[This corrects the article DOI: 10.1371/journal.pone.0079461.].
متن کاملA family of genus‐specific RNAs in tandem with DNA‐binding proteins control expression of the badA major virulence factor gene in Bartonella henselae
Bartonella henselae is a gram-negative zoonotic bacterium that causes infections in humans including endocarditis and bacillary angiomatosis. B. henselae has been shown to grow as large aggregates and form biofilms in vitro. The aggregative growth and the angiogenic host response requires the trimeric autotransporter adhesin BadA. We examined the transcriptome of the Houston-1 strain of B. hens...
متن کاملStructure of the Head of the Bartonella Adhesin BadA
Trimeric autotransporter adhesins (TAAs) are a major class of proteins by which pathogenic proteobacteria adhere to their hosts. Prominent examples include Yersinia YadA, Haemophilus Hia and Hsf, Moraxella UspA1 and A2, and Neisseria NadA. TAAs also occur in symbiotic and environmental species and presumably represent a general solution to the problem of adhesion in proteobacteria. The general ...
متن کاملTrimeric autotransporter adhesin-dependent adherence of Bartonella henselae, Bartonella quintana, and Yersinia enterocolitica to matrix components and endothelial cells under static and dynamic flow conditions.
Trimeric autotransporter adhesins (TAAs) are important virulence factors of Gram-negative bacteria responsible for adherence to extracellular matrix (ECM) and host cells. Here, we analyzed three different TAAs (Bartonella adhesin A [BadA] of Bartonella henselae, variably expressed outer membrane proteins [Vomps] of Bartonella quintana, and Yersinia adhesin A [YadA] of Yersinia enterocolitica) f...
متن کاملStructure of a Burkholderia pseudomallei Trimeric Autotransporter Adhesin Head
BACKGROUND Pathogenic bacteria adhere to the host cell surface using a family of outer membrane proteins called Trimeric Autotransporter Adhesins (TAAs). Although TAAs are highly divergent in sequence and domain structure, they are all conceptually comprised of a C-terminal membrane anchoring domain and an N-terminal passenger domain. Passenger domains consist of a secretion sequence, a head re...
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ژورنال
عنوان ژورنال: npj Biofilms and Microbiomes
سال: 2019
ISSN: 2055-5008
DOI: 10.1038/s41522-019-0083-8